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general informaiton about cbd

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  • The Science Behind CBD

CBD is one of the primary active ingredients in marijuana. While it has spent years in the shadow of THC (which is well-known for its intoxicating high), the effects of CBD are just as important when it comes to how marijuana makes people feel. To comprehend how cannabidiol affects the brain and body, it helps to understand cannabinoids.


How Does CBD Work? 

Back in the early 60s, a group of Israeli researchers led by Dr. Raphael Mechoulam decided to conduct tests on marijuana to figure out how it worked. By then, scientists had discovered that morphine was the active ingredient in the opium plant and that cocaine was the highly addictive substance in cacao leaves, but they still had no idea what caused the signature high when someone ingested marijuana.The first ingredient they isolated in cannabis was CBD (they wouldn’t find THC until about a year later), and along with THC and dozens of other compounds in marijuana, it’s classified as a cannabinoid.What are cannabinoids? They plug into the receptors in the brain to create various side effects. For example, THC binds to CB1 and CB2 receptors to make people feel high, happy, or sleepy. While CBD doesn’t bind well with either of those receptors, it indirectly affects them by stimulating the body to create its own cannabinoids (known as endocannabinoids). It also acts on non-cannabinoid receptor systems to create relaxation and kill pain.

CBD & the Entourage Effect

Mechoulam and his team noted that while each cannabinoid had a specific effect when used individually, they seemed to work better when used together. CBD features none of the intoxicating effects of THC. Also, when CBD and THC are used at a 2:1 ratio, the combination cancels out the high created by THC. This means that patients can use THC to quell their nausea or stimulate their appetites without feeling intoxicated, experiencing a fast heartbeat, or dealing with anxiety. Mechoulam named this phenomenon the entourage effect  and it’s one of the reasons why medical marijuana proponents push hard for legal use of whole-plant cannabis. While minor cannabinoids such as CBC and THCV may not have noticeable effects, they work in subtle ways to boost their cannabinoid siblings.

CBD Side Effects

As CBD has gained more attention, people want to know more about its effects. Does CBD create a high if it’s isolated and consumed as a concentrate (in an oil, for instance)? Does it have any negative side effects? As with any substance, it’s important to know what to expect before consuming high doses of CBD oil or any type of concentrate.

CBD effects include: 

  • Relaxation
  • Drowsiness
  • Light-headedness
  • Dry mouth
  • A drop in blood pressure
  • Diarrhea
  • Changes in appetite

What does CBD feel like? CBD doesn’t create a high the way ingesting a THC-rich marijuana strain does. Instead, it often leaves users feeling clear-headed. Many people report feeling a general sense of relaxation and well-being after they take it by itself or use a high-CBD strain of cannabis.

Because everyone’s brain, body, and metabolism are different, there’s no guarantee what the effects of cannabidiol will be. Doses of up to 600 mg are considered a good place to start. It’s rare to hear of negative side effects with CBD, but as with any drug, it’s best to start with a lower dose and give it time to determine its effects. Generally, people find that the benefits far outweigh any negative side effects. If someone did take a large enough dose to create a “CBD high,” it would likely consist of feeling lightheaded and sleepy.

CBD Precautions

While studies have shown CBD to be well-tolerated and safe, it should be treated like any other drug or supplement. This means that people with health conditions should talk to their doctors before using CBD (whether in whole-plant marijuana or any form). This includes:

• Women who are pregnant/breastfeeding:
At this time, there’s not enough reliable information to know whether or not CBD may pose a risk to a fetus or breastfeeding infant.

• Those taking pharmaceutical drugs:

Because CBD interacts with the body’s cytochrome P-450 system, anyone taking medications should talk to their doctor or pharmacist about any potential interactions.


Why Combine CBD & THC?

While CBD is a useful cannabinoid in its own right, it’s even more useful when it’s combined with THC. This is because of the way the two compounds behave when paired together.People use THC to treat many different diseases and disorders. Cancer patients, for example, have found that THC can help reduce the nausea and vomiting they experience after a strong dose of chemo. For some, though, the psychoactive effects of THC are too much. They need to go about their day without feeling high or can’t stand how THC sends their heart rate and anxiety levels skyrocketing.When CBD is added into the equation, the side effects of THC that aren’t helpful in medical treatments begin to lessen. At a 2:1 CBD-to-THC ratio, the psychoactive effects of THC disappear entirely. This feature of the “entourage effect” enables people to use THC as medicine without any of the unwanted side effects.THC also helps CBD out by making it work better at treating certain conditions. Parents of children with Dravet syndrome (a severe type of childhood epilepsy) have discovered that high doses of CBD can help where no other medications can. For some kids, however, a mix of THC and CBD gets the best results.

Medical Benefits

Over the last couple of decades, laws have been passed that legalize medical marijuana (including CBD oil and concentrates) in a growing number of places. As the medical use of cannabis continues to spread, so do stories about its efficacy for a wide variety of conditions. To get the proper medicine, however, it’s essential that patients understand which conditions CBD is effective at treating as opposed to ones that are better treated with THC. Studies are revealing that CBD is useful for treating diseases and ailments that range from anxiety to epilepsy.

General Medical Uses for CBD 

While cannabidiol is showing promise as a treatment for many different medical conditions, it’s not a cure-all. To find out what conditions CBD can actually treat, as well as the ones for which it’s potentially effective, it helps to look at what the science says. Study after study has shown that CBD Health benefits are wide-ranging. The compound shows promise for the following uses:

Anti-inflammatory. CBD has been studied as an anti-inflammatory for conditions such as rheumatoid arthritis. In this disease, inflammatory responses in the body cause pain and swelling. In studies on mice, CBD showed immunosuppressive  and antiimflammatory properties that stopped the progression of the disease

Antidepressan. Anandamide, also known as “the bliss molecule,” is a chemical naturally found in the brain. It binds with cannabinoid receptors there and acts as a mood-booster. CBD slows the brain’s breakdown of anandamide, therefore acting as a natural antidepressant.

Cancer-fighter In addition to all of this, preclinical studies have shown that cannabidiol may fight cancer – at least in in a laboratory setting. In certain types of cancer, it kills the cells, stops them from growing, and prevents them from developing new blood vessels. More studies are necessary to see how this might be translated into medical treatments for people battling cancer.

Scientists are conducting a slew of studies to determine whether humans can use CBD to battle everything from chronic pain to opioid addiction. While many studies show promise, it’s important for people to talk to their doctors before modifying their medical treatment. It’s also important to put studies about CBD health benefits into context in terms of concentrations, dosage, and application methods that were used, as well as whether or not the tests have been successfully conducted on humans.


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